Approaches to uncovering cancer diagnostic and prognostic molecular signatures

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Approaches to uncovering cancer diagnostic and prognostic molecular signatures

The recent rapid development of high-throughput technology enables the study of molecular signatures for cancer diagnosis and prognosis at multiple levels, from genomic and epigenomic to transcriptomic. These unbiased large-scale scans provide important insights into the detection of cancer-related signatures. In addition to single-layer signatures, such as gene expression and somatic mutations...

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Derivation of cancer diagnostic and prognostic signatures from gene expression data.

The ability to compare genome-wide expression profiles in human tissue samples has the potential to add an invaluable molecular pathology aspect to the detection and evaluation of multiple diseases. Applications include initial diagnosis, evaluation of disease subtype, monitoring of response to therapy and the prediction of disease recurrence. The derivation of molecular signatures that can pre...

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Gene Expression Deconvolution for Uncovering Molecular Signatures in Response to Therapy in Juvenile Idiopathic Arthritis

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ژورنال

عنوان ژورنال: Molecular & Cellular Oncology

سال: 2014

ISSN: 2372-3556

DOI: 10.4161/23723548.2014.957981